Functional Improvement of Regulatory T Cells from Rheumatoid Arthritis Subjects Induced by Capsular Polysaccharide Glucuronoxylomannogalactan
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منابع مشابه
Functional Improvement of Regulatory T Cells from Rheumatoid Arthritis Subjects Induced by Capsular Polysaccharide Glucuronoxylomannogalactan
OBJECTIVE Regulatory T cells (Treg) play a critical role in the prevention of autoimmunity, and the suppressive activity of these cells is impaired in rheumatoid arthritis (RA). The aim of the present study was to investigate function and properties of Treg of RA patients in response to purified polysaccharide glucuronoxylomannogalactan (GXMGal). METHODS Flow cytometry and western blot analys...
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Regulatory T (Treg) cells have emerged as a distinct subset of lymphocytes that are responsible for limiting immune responses and avoiding pathologic autoimmunity. Evidence is accumulating that defects in Treg function are important in immune-mediated diseases such as rheumatoid arthritis (RA). We discuss herein the biology of Treg cells and emphasize what is known about Treg dysfunction in RA.
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0111163